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pentobarbital will minimize the level or influence of colchicine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will lessen the level or influence of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Loss of, or reduced response to tofacitinib could arise when coa